Marchione Pasquale, Ghiotto Natascia, Sances Grazia, Guaschino Elena, Bosone D, Nappi G, Giacomini Patrizia
Neurovascular Unit, Department of Neurology and Otorhinolaringology, University La Sapienza, Rome, Italy.
Funct Neurol. 2008 Oct-Dec;23(4):201-5.
The high incidence of patent foramen ovale (PFO) in migraine with aura (MWA) is well known. In this study we evaluated the relationship between PFO and aura features, and the relative impact of this association on stroke risk. We recruited patients with a diagnosis of MWA. PFO was assessed by contrast transcranial Doppler and confirmed by transoesophageal echocardiography. The 65 patients enrolled were divided into two groups on the basis of the clinical features of their aura: typical in 63.1% (Group 1) and atypical in 36.9% (Group 2). A statistically significant difference was found in PFO prevalence between the two groups (46.3% in Group 1 and 79.2% in Group 2; p=0.009). We did not observe any statistical difference between the two groups in the prevalence of classic stroke risk factors or in the profile of the thrombophilic markers. Our results underline the need to look for PFO particularly in subjects with atypical features of aura, but the underlying pathophysiology of the association is not clear.
卵圆孔未闭（PFO）在伴有先兆的偏头痛（MWA）中高发已为人熟知。在本研究中，我们评估了PFO与先兆特征之间的关系，以及这种关联对中风风险的相对影响。我们招募了被诊断为MWA的患者。通过经颅多普勒对比检查评估PFO，并经食管超声心动图确认。根据先兆的临床特征，将纳入的65例患者分为两组：63.1%为典型先兆（第1组），36.9%为非典型先兆（第2组）。两组之间PFO患病率存在统计学显著差异（第1组为46.3%，第2组为79.2%；p = 0.009）。我们未观察到两组在经典中风危险因素患病率或血栓形成倾向标志物方面存在任何统计学差异。我们的结果强调了尤其需要在具有非典型先兆特征的受试者中寻找PFO，但这种关联的潜在病理生理学尚不清楚。
