Stein Paul D, Gottschalk Alexander, Sostman H Dirk, Chenevert Thomas L, Fowler Sarah E, Goodman Lawrence R, Hales Charles A, Hull Russell D, Kanal Emanuel, Leeper Kenneth V, Nadich David P, Sak Daniel J, Tapson Victor F, Wakefield Thomas W, Weg John G, Woodard Pamela K
Department of Research, St. Joseph Mercy Oakland Hospital, Pontiac, MI 48341-5023, USA.
Semin Nucl Med. 2008 Nov;38(6):462-70. doi: 10.1053/j.semnuclmed.2008.06.003.
In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.
在本研究中,详细描述了肺栓塞诊断前瞻性研究III(PIOPED III)的方法。PIOPED III是一项由美国国立心肺血液研究所赞助的多中心协作研究。其目的是确定钆增强磁共振血管造影联合静脉期磁共振静脉造影对急性肺栓塞(PE)诊断的准确性。采用基于PE常用诊断方法的综合参考标准。所有图像将由两名不知情且经过研究认证的中心阅片者进行解读。根据综合参考测试无PE的患者将被随机分组,接受钆增强磁共振血管造影联合静脉期磁共振静脉造影检查。该程序将在不损失敏感性和特异性评估的情况下降低检查结果为阴性的患者比例。