Koulouris Carolyn R, Penson Richard T
Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Semin Oncol. 2009 Apr;36(2):126-36. doi: 10.1053/j.seminoncol.2008.12.004.
Cancers arising from the stromal and germ cell layers of the ovary are rare, heterogeneous, difficult to study, and require specialized multidisciplinary management. We present a clinically relevant review of the literature of these malignancies, with particular emphasis on the more typical presentations. These tumors more commonly present in younger patients and have a high cure rate. They are associated with serum markers that are informative for diagnosis and surveillance. Surgery is often part of primary treatment, with staging and preservation of fertility being important priorities. Most patients with germ cell tumors require adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (BEP), as well as careful surveillance. The rarity of these tumors makes basic scientific advances more challenging.
起源于卵巢基质和生殖细胞层的癌症较为罕见，具有异质性，难以研究，需要专门的多学科管理。我们对这些恶性肿瘤的文献进行了具有临床相关性的综述，特别强调了更典型的表现。这些肿瘤更常见于年轻患者，治愈率高。它们与有助于诊断和监测的血清标志物有关。手术通常是主要治疗的一部分，分期和保留生育能力是重要的优先事项。大多数生殖细胞肿瘤患者需要使用博来霉素、依托泊苷和顺铂（BEP）进行辅助化疗，以及仔细的监测。这些肿瘤的罕见性使得基础科学进展更具挑战性。
