Pucci Angela, Zanini Cristina, Granata Riccarda, Ghignone Roberta, Iavarone Alberto, Broglio Fabio, Sorrentino Paolo, Bergamasco Laura, Rinaldi Mauro, Ghigo Ezio
Department of Pathology, Regina Margherita Hospital, Torino, Italy.
J Heart Lung Transplant. 2009 Apr;28(4):402-5. doi: 10.1016/j.healun.2008.12.022.
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.
胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白（IGFBPs）可能在心力衰竭中发挥致病作用。我们发现，与10例对照相比，23例因终末期扩张型或缺血性心肌病接受心脏移植患者的衰竭心脏中，心肌IGFBP-3表达（通过实时聚合酶链反应检测）和细胞凋亡（通过流式细胞术检测）显著增加。仅在终末期扩张型心肌病中显示出较高的IGF-1 mRNA水平。
