评论：基于细胞的癫痫治疗前景
Commentary: the prospect of cell-based therapy for epilepsy.
作者信息
Kriegstein Arnold R, Pitkänen Asla
机构信息
Department of Neurology, University of California, San Francisco, California 94143-0525, USA.
出版信息
Neurotherapeutics. 2009 Apr;6(2):295-9. doi: 10.1016/j.nurt.2009.01.013.
Abstract
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel approaches are needed to prevent or alleviate epileptogenic process after various types of brain injuries. The use of cell transplants as factories to produce endogeneous anticonvulsants or as bricks to repair abnormal ictogenic and epileptogenic neuronal circuits has generated hope that cell-based therapies could become a novel therapeutic category in the treatment arsenal of epilepsy. Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy.
摘要
约30%的癫痫患者对现有的抗癫痫药物没有反应。除了抑制癫痫发作外，还需要新的方法来预防或减轻各种类型脑损伤后的致痫过程。将细胞移植用作产生内源性抗惊厥药物的工厂或用作修复异常致痫和癫痫发作神经元回路的砖块，这让人们产生了希望，即基于细胞的疗法可能会成为癫痫治疗手段中的一种新型治疗方法。在此，我们总结了基于细胞的疗法在癫痫治疗中的现状和未来前景。
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