de Barros André Luís Branco, Cardoso Valbert Nascimento, Mota Luciene das Graças, Leite Elaine Amaral, Oliveira Mônica Cristina de, Alves Ricardo José
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.
Bioorg Med Chem Lett. 2009 May 1;19(9):2497-9. doi: 10.1016/j.bmcl.2009.03.059. Epub 2009 Mar 18.
A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, d-glucose-MAG(3) is a potential agent for tumor diagnosis.
成功合成了一种d-葡萄糖-MAG(3)衍生物，并以高标记产率进行了放射性标记。对荷艾氏瘤小鼠进行了生物分布研究。该化合物在肿瘤组织中高度蓄积，肿瘤与肌肉的比值高，肿瘤与血液的比值适中。因此，d-葡萄糖-MAG(3)是一种潜在的肿瘤诊断剂。
