一种用锝-99m标记的新型D-葡萄糖衍生物：在艾氏腹水癌实验模型中的合成、生物分布研究及闪烁显像
A novel D-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor.
作者信息
de Barros André Luís Branco, Cardoso Valbert Nascimento, Mota Luciene das Graças, Leite Elaine Amaral, de Oliveira Mônica Cristina, Alves Ricardo José
机构信息
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2478-80. doi: 10.1016/j.bmcl.2010.03.003. Epub 2010 Mar 3.
A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Thus, d-glucose-MAG(3) could be considered as agent for tumor diagnosis.
成功合成了一种d-葡萄糖-MAG(3)衍生物，并以高标记率进行了放射性标记。对荷艾氏瘤小鼠进行了生物分布研究和闪烁扫描成像。该化合物在肿瘤组织中高度蓄积，肿瘤与肌肉的比值很高。因此，d-葡萄糖-MAG(3)可被视为肿瘤诊断剂。
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