Sawle G V, Hymas N F, Lees A J, Frackowiak R S
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Brain. 1991 Oct;114 ( Pt 5):2191-202. doi: 10.1093/brain/114.5.2191.
Patients with Obsessional Slowness (OS) exhibit extreme slowness in the execution of some everyday tasks, such as washing and eating. This may be due to time-consuming rituals, checking behaviour and compulsions. On examination some have neurological signs such as a glabellar tap reflex, cogwheel rigidity or abnormal postures. The purpose of this study was to establish a functional explanation for slowness in this patient group. We have studied 6 OS patients using positron emission tomography (PET) with (15)Oxygen to measure regional cerebral oxygen metabolism and [18F]-6-Fluorodopoa (18F-dopa) to assess the integrity of the presynaptic nigrostriatal system. The findings were of focal hypermetabolism in orbital frontal, premotor and midfrontal cortex, whilst dopa uptake into caudate, putamen and medial frontal cortex was normal. The relationship of these findings to the patients' slowness is discussed.
强迫性迟缓（OS）患者在执行某些日常任务（如洗漱和进食）时表现出极度迟缓。这可能是由于耗时的仪式行为、检查行为和强迫行为所致。检查时，一些患者有神经学体征，如眉间轻叩反射、齿轮样强直或异常姿势。本研究的目的是为该患者群体的迟缓建立一种功能性解释。我们使用正电子发射断层扫描（PET）对6名OS患者进行了研究，用（15）氧测量局部脑氧代谢，并用[18F]-6-氟多巴（18F-多巴）评估突触前黑质纹状体系统的完整性。研究结果显示眶额皮质、运动前区和额中回皮质有局灶性代谢亢进，而尾状核、壳核和额内侧皮质的多巴摄取正常。本文讨论了这些发现与患者迟缓之间的关系。
