Kincaid A E, Penney J B, Young A B, Newman S W
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109.
Brain Res. 1991 Jul 5;553(1):18-26. doi: 10.1016/0006-8993(91)90224-j.
Study of the afferents of the rat globus pallidus (GP) with Fluoro-gold, a retrograde tracer, revealed retrogradely labeled neurons in the ipsilateral parafascicular nucleus of the thalamus (PF), a previously undescribed afferent of the rat GP. We used the anterograde tracer, Phaseolus vulgaris-leucoagglutinin (PHA-L), to confirm and extend our findings. After injections of PHA-L in the PF, labeled fibers with varicosities and terminal specializations were observed in the ipsilateral GP. The topographical organization of the projection is such that lateral and ventral PF neurons project preferentially to respective parts of the GP, and medial PF neurons project primarily to the ventral GP. There were very few labeled fibers seen in the dorsal or medial GP. The presently described projection from the PF to the GP provides an additional route for the PF to influence basal ganglia circuitry.
用逆行示踪剂荧光金对大鼠苍白球（GP）的传入神经进行研究，结果显示在丘脑束旁核（PF）的同侧有逆行标记的神经元，这是大鼠GP之前未被描述的传入神经。我们使用顺行示踪剂菜豆凝集素（PHA-L）来证实并扩展我们的发现。在PF注射PHA-L后，在同侧GP中观察到有膨体和终末特化的标记纤维。这种投射的拓扑组织是，外侧和腹侧PF神经元优先投射到GP的相应部分，内侧PF神经元主要投射到腹侧GP。在背侧或内侧GP中可见的标记纤维非常少。目前所描述的从PF到GP的投射为PF影响基底神经节回路提供了一条额外的途径。
