Chen Weirong, Chen Maogen, Liao Ziqun, Wang Yuhong, Zhan Qinhua, Cai Gaoyang
Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Dis Colon Rectum. 2009 Mar;52(3):513-9. doi: 10.1007/DCR.0b013e31819a2498.
This study identified possible factors affecting the frequency of local recurrence of rectal cancer, focusing on lymphangiogenesis as a predictor.
We examined 352 primary rectal cancer cases and 34 local recurrent specimens by lymphatic hyaluronan receptor. The lymphangiogenesis of all specimens was evaluated by measuring by lymphatic vessel density and other clinicopathologic factors.
A multivariate analysis using the Cox proportional hazard model showed that lymphatic vessel density, lymph node metastasis, depth of invasion, and lymphatic invasion were significant independent predictive factors of local recurrence; lymphatic vessel density was the strongest predictor. In addition, a significant correlation was found between the lymphatic vessel density of the primary rectal cancer and the corresponding local recurrent cases.
We suggest that rectal cancers, which have active lymphangiogenesis, also demonstrate a greater potential for local recurrence, and the lymphatic vessel density of surgical specimens is an independent risk factor and a valuable predictive factor for the local recurrence of rectal cancer.
本研究确定了影响直肠癌局部复发频率的可能因素，重点关注淋巴管生成作为预测指标。
我们通过淋巴管透明质酸受体检查了352例原发性直肠癌病例和34例局部复发标本。通过测量淋巴管密度和其他临床病理因素评估所有标本的淋巴管生成情况。
使用Cox比例风险模型进行的多变量分析表明，淋巴管密度、淋巴结转移、浸润深度和淋巴管浸润是局部复发的显著独立预测因素；淋巴管密度是最强的预测因素。此外，在原发性直肠癌的淋巴管密度与相应的局部复发病例之间发现了显著相关性。
我们认为，具有活跃淋巴管生成的直肠癌也具有更高的局部复发潜力，手术标本的淋巴管密度是直肠癌局部复发的独立危险因素和有价值的预测因素。
