Blümcke I, Hof P R, Morrison J H, Celio M R
Institute of Anatomy, University of Kiel, F.R.G.
Brain Res. 1991 Jul 19;554(1-2):237-43. doi: 10.1016/0006-8993(91)90195-2.
Parvalbumin (PV) is present in a subpopulation of interneurons in the visual cortex, and also in thalamic afferents to the neocortex of primates. The object of this study is to confirm by immunoelectron-microscopy the presence of intrinsic and extrinsic connections containing parvalbumin in the monkey visual cortex, by the demonstration of parvalbumin-immunoreactivity in symmetric and asymmetric synapses. We analyzed the distribution of parvalbumin-immunoreactive profiles at the ultrastructural level in the primary visual cortex of old world monkeys (Macaca fascicularis). It has been shown by others that parvalbumin-immunoreactive cells resemble non-spiny stellate cells, double-bouquet cells, chandelier and basket cells. These neurons are known to be inhibitory and to form symmetric synapses. In fact, we observed that the vast majority of parvalbumin-immunoreactive synaptic contacts in the primary visual cortex of Macaca fascicularis are of the symmetric type (81.7%). Since parvalbumin-positive asymmetric contacts are also present (18.3%) and occur mostly in the thalamic recipient layers, 4C and 4A (9.9%), these afferents probably derive from parvalbumin-immunoreactive neurons located in the dorsal lateral geniculate nucleus of the thalamus.
小白蛋白（PV）存在于视觉皮层的一部分中间神经元中，在灵长类动物新皮层的丘脑传入纤维中也有表达。本研究的目的是通过免疫电子显微镜，通过显示对称和不对称突触中的小白蛋白免疫反应性，来证实猴视觉皮层中存在含有小白蛋白的内在和外在连接。我们在旧世界猴（食蟹猴）的初级视觉皮层中，在超微结构水平上分析了小白蛋白免疫反应性轮廓的分布。其他人已经表明，小白蛋白免疫反应性细胞类似于无棘星状细胞、双花束细胞、吊灯细胞和篮状细胞。已知这些神经元具有抑制作用并形成对称突触。事实上，我们观察到食蟹猴初级视觉皮层中绝大多数小白蛋白免疫反应性突触接触是对称型的（81.7%）。由于也存在小白蛋白阳性的不对称接触（18.3%），且大多发生在丘脑接受层4C和4A（9.9%），这些传入纤维可能来自位于丘脑背侧外侧膝状核的小白蛋白免疫反应性神经元。
