Aregawi Dawit, Lopez David, Wick Mark, Scheld W Michael, Schiff David
Neuro-Oncology Center and Departments of Neurology, Neurological Surgery, and Medicine (Hematology-Oncology), University of Virginia, Charlottesville, VA 22908-0432, USA.
J Neurooncol. 2009 Sep;94(3):439-43. doi: 10.1007/s11060-009-9878-4. Epub 2009 Mar 31.
Strongyloides stercoralis is an intestinal parasite that can cause fatal opportunistic infections in immunocompromised patients. Here we report an immunocompromised patient with glioblastoma who developed disseminated strongyloidiasis 6 weeks after completion of standard radiotherapy and concurrent temozolomide chemotherapy. She was effectively treated with albendazole and ivermectin. Strongyloidiasis should be considered in patients being treated for glioma who have lived or traveled to high risk areas and developed gram negative sepsis, along with gastrointestinal or respiratory symptoms, skin rash or SIADH.
粪类圆线虫是一种肠道寄生虫，可在免疫功能低下的患者中引起致命的机会性感染。在此，我们报告一名患有胶质母细胞瘤的免疫功能低下患者，在完成标准放疗和同步替莫唑胺化疗6周后发生播散性粪类圆线虫病。她接受阿苯达唑和伊维菌素治疗后病情得到有效控制。对于曾生活或前往高危地区、出现革兰氏阴性菌败血症以及伴有胃肠道或呼吸道症状、皮疹或抗利尿激素分泌异常综合征（SIADH）的胶质瘤治疗患者，应考虑粪类圆线虫病的可能。
