Asztely F, Hanse E, Wigström H, Gustafsson B
Department of Physiology, University of Göteborg, Sweden.
Brain Res. 1991 Aug 30;558(1):153-6. doi: 10.1016/0006-8993(91)90734-d.
The effect of local pressure application of N-methyl-D-aspartate (NMDA) in the synaptic layer of CA1 pyramidal cells was investigated in the guinea pig hippocampal slice preparation using extracellular recording technique. Application of NMDA produced a transient depression and a subsequent 30-60 min potentiation of the field excitatory postsynaptic potential (EPSP) seen as an increase of the initial slope and amplitude of the EPSP. The increase in amplitude was consistently greater than that of the initial slope. Prior tetanization that caused saturation of long-term potentiation prevented the generation of an NMDA-induced potentiation of the initial slope for more than 1-2 h, but not the generation of an increase of the amplitude.
在豚鼠海马脑片标本中，使用细胞外记录技术研究了在CA1锥体细胞突触层局部施加N-甲基-D-天冬氨酸（NMDA）的作用。施加NMDA会产生短暂的抑制，随后场兴奋性突触后电位（EPSP）增强30 - 60分钟，表现为EPSP初始斜率和幅度增加。幅度的增加始终大于初始斜率的增加。先前引起长期增强饱和的强直刺激可在1 - 2小时以上阻止NMDA诱导的初始斜率增强，但不会阻止幅度增加的产生。
