脑蛋白激酶C同工酶对油酸乙酯（一种酒精代谢产物）的反应。
Response of brain protein kinase C isozymes to ethyl oleate, an alcohol metabolite.
作者信息
Holian O, Ruiz C, Kumar R, Nyhus L M
机构信息
Department of Surgery, College of Medicine, University of Illinois, Chicago 60612.
出版信息
Brain Res. 1991 Aug 30;558(1):98-100. doi: 10.1016/0006-8993(91)90720-g.
Rat brain protein kinase C (PKC) isozymes I, II and III were stimulated by fatty acids in the absence and presence of calcium. Ethyl oleate, which by itself has no effect on PKC activity, had a potentiating effect on fatty acid-induced activation of all 3 isozymes. Potentiation was observed predominantly in the presence of calcium. Interaction of ethyl oleate with a signalling mechanism involving PKC may underlie the cognitive disturbances noted after alcohol consumption.
在有钙和无钙的情况下，大鼠脑蛋白激酶C（PKC）同工酶I、II和III均受到脂肪酸的刺激。油酸乙酯本身对PKC活性没有影响，但对脂肪酸诱导的所有3种同工酶的激活具有增强作用。这种增强作用主要在有钙的情况下观察到。油酸乙酯与涉及PKC的信号传导机制之间的相互作用可能是饮酒后出现认知障碍的基础。
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