Boscá L, Díaz-Guerra M J, Mojena M
Instituto de Bioquimica, Facultad de Farmacia, Madrid, Spain.
Biochem Biophys Res Commun. 1989 May 15;160(3):1243-9. doi: 10.1016/s0006-291x(89)80137-8.
The incubation of rat liver homogenates in the presence of oleate induces the translocation of protein kinase C from the cytosol to the endoplasmic reticulum membranes. The half-maximal effect was obtained at 0.3 mM oleate. The redistribution of this enzyme induced by oleate was also obtained with purified protein kinase C and hepatic microsomal membranes. This effect seems to be mediated by long-chain fatty acids since translocation was not obtained with esterified derivatives.
在油酸存在的情况下孵育大鼠肝脏匀浆会诱导蛋白激酶C从胞质溶胶转位至内质网膜。在0.3 mM油酸浓度下可获得半数最大效应。用纯化的蛋白激酶C和肝微粒体膜也可观察到油酸诱导的这种酶的重新分布。这种效应似乎是由长链脂肪酸介导的，因为酯化衍生物不能诱导转位。
