Di Pirro J M, Thompson A C, Kristal M B
Department of Psychology, State University of New York, Buffalo 14260.
Brain Res Bull. 1991 Jun;26(6):851-5. doi: 10.1016/0361-9230(91)90248-i.
Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.
羊水和胎盘含有一种物质（POEF），摄入该物质会增强多种药物（吗啡注射、阴道/宫颈刺激、妊娠晚期、足部电击）产生的阿片类药物介导的镇痛作用，但不会增强阿司匹林注射产生的镇痛作用。本系列实验使用季铵型纳曲酮（一种不易穿过血脑屏障的阿片类拮抗剂），结合吗啡的外周或中枢给药，以确定摄入羊水（进而摄入POEF）是否通过影响吗啡的中枢和/或外周作用来增强阿片类药物介导的镇痛作用。结果表明，POEF仅影响吗啡的中枢镇痛作用。
