Riekkinen P, Koivisto E, Sirviö J, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res Bull. 1991 Jul;27(1):137-9. doi: 10.1016/0361-9230(91)90296-v.
A combination of subthreshold doses of nicotinic and muscarinic antagonist induced an increase in all the spectral components. The spectral amplitude change induced by a large scopolamine dose could not be augmented by either mecamylamine or an additional injection of scopolamine. NB lesions increased frontal slow wave activity (delta and theta amplitudes). Single or combined injections of scopolamine and mecamylamine produced a significantly smaller change in the frontal EEG amplitude values of NB-lesioned rats than in controls.
亚阈值剂量的烟碱样和毒蕈碱样拮抗剂联合使用可使所有频谱成分增加。大剂量东莨菪碱引起的频谱幅度变化，不能被美加明或额外注射东莨菪碱增强。去大脑皮层（NB）损伤可增加额叶慢波活动（δ波和θ波幅度）。与对照组相比，单独或联合注射东莨菪碱和美加明，去大脑皮层损伤大鼠额叶脑电图幅度值的变化显著较小。
