Osipenko M F, Venzhina Iu Iu
Ter Arkh. 2009;81(2):62-5.
To analyse course of excretory pancreatic insufficiency (EPI) of pancreatic and not origin as well as factors associated with its development.
A total of 139 patients with chronic pancreatitis or malabsorption were examined. The pancreatic function was assessed by the results of elastase test - concentration of pancreatic elastase 1 in the feces. EPI was detected in 57 patients (fecal pancreatic elastase 1 under 200 mcg/g); 38 patients had chronic pancreatitis and absolute EPI, 19 patients had relative EPI (the elastase was low, pancreatic pathology was absent, but other gastroenterological diseases were present--enteropathy, Crohn's disease, previous surgery).
Pancreatic insufficiency in patients with pancreatitis was 36.5%. It was associated with the disease duration. Diarrheal and asthenic syndromes, normal or low lipase levels in the serum were found. Patients with relative insufficiency were significantly younger, had shorter disease duration, more frequent diarrhea, were thinner. Correction of diarrheal syndrome was more successful in patients with absolute insufficiency. Pancreatic elastase concentration in the feces persisted for a year in patients with absolute EPI and normalized in patients with enteropathies after etiotropic and pathogenetic therapy.
分析非胰腺源性排泄性胰腺功能不全（EPI）的病程及其发展相关因素。
共检查了139例慢性胰腺炎或吸收不良患者。通过弹性蛋白酶检测结果评估胰腺功能——粪便中胰腺弹性蛋白酶1的浓度。57例患者检测到EPI（粪便胰腺弹性蛋白酶1低于200 mcg/g）；38例患者患有慢性胰腺炎和绝对EPI，19例患者患有相对EPI（弹性蛋白酶水平低，无胰腺病变，但存在其他胃肠疾病——肠病、克罗恩病、既往手术史）。
胰腺炎患者的胰腺功能不全发生率为36.5%。它与病程有关。发现有腹泻和虚弱综合征，血清脂肪酶水平正常或降低。相对功能不全的患者明显更年轻，病程更短，腹泻更频繁，体型更瘦。绝对功能不全患者的腹泻综合征纠正更成功。绝对EPI患者粪便中的胰腺弹性蛋白酶浓度持续一年，肠病患者经病因和发病机制治疗后粪便中的胰腺弹性蛋白酶浓度恢复正常。
