Nesterov Iu I, Bondareva I N, Tepliakov A T, Poltavtseva O V
Ter Arkh. 2009;81(2):75-9.
To investigate antihypertensive efficacy, effects on endothelial, diastolic function of the left ventricle and metabolism of combination of ACE inhibitor quinapril (accupro) with diuretic indapamide SR in patients with hypertension of the second-third degree and type 2 diabetes mellitus (DM) and free of DM.
Outpatient treatment was given to 60 patients with AH (mean age 55.3 +/- 9.6 years) in combination with mild or moderate DM (group 1) and free of DM (group 2). The patients were observed for 12 weeks. Clinical and biochemical blood tests, ECG, echo-CG, measurements of blood pressure were made in all the patients.
Quinapril course (mean dose 23.3 +/- 9.8 mg/day) in combination with indapamide (1.5 mg/ day) produced a complete hypotensive effect in group 1 (23 patients, 76.7%), in group 2--25 (83.3%). DM patients demonstrated reduction of fasting and postprandial glycemia and cholesterol, time of isovolumic relaxation reduced in group 1 by 9.1%, in group 2 by 19.8% (p < 0.01). Left ventricular diastolic function improved, endothelium-dependent vasodilation in diabetics rose by 40%, non-endothelium-dependent--by 21.8%, in hypertensive patients free of DM--by 51.9 and 43.2%, respectively.
Combination of quinapril with indapamide produces a significant antihypertensive effect in patients with AH of degree II-III associated with type 2 DM, improves carbohydrate and lipid metabolism, left ventricular diastolic function.
研究血管紧张素转换酶抑制剂喹那普利（Accupro）与利尿剂吲达帕胺缓释剂联合应用对二至三级高血压合并2型糖尿病（DM）患者及无糖尿病患者的降压疗效、对内皮功能、左心室舒张功能和代谢的影响。
对60例高血压患者（平均年龄55.3±9.6岁）进行门诊治疗，其中合并轻度或中度糖尿病的患者为1组，无糖尿病的患者为2组。对患者进行12周的观察。对所有患者进行临床和生化血液检查、心电图、超声心动图检查以及血压测量。
喹那普利疗程（平均剂量23.3±9.8毫克/天）与吲达帕胺（1.5毫克/天）联合应用，在1组（23例患者，76.7%）和2组（25例患者，83.3%）产生了完全降压效果。糖尿病患者的空腹和餐后血糖及胆固醇降低，1组等容舒张时间减少9.1%，2组减少19.8%（p<0.01）。左心室舒张功能改善，糖尿病患者内皮依赖性血管舒张增加40%，非内皮依赖性血管舒张增加21.8%，无糖尿病的高血压患者分别增加51.9%和43.2%。
喹那普利与吲达帕胺联合应用对二至三级高血压合并2型糖尿病患者具有显著降压效果，可改善碳水化合物和脂质代谢以及左心室舒张功能。
