[阿福唑在波索尔特和野村试验中的抗抑郁特性]
[Antidepressant properties of afobazole in Porsolt and Nomura tests].
作者信息
Seredenin S B, Molodavkin G M, Voronin M V, Voronina T A
出版信息
Eksp Klin Farmakol. 2009 Jan-Feb;72(1):19-21.
PMID:19334505
Abstract
Anxiolytic afobazole was shown in the experiments on outbred rats to decrease the immobility in the Porsolt and Nomura swim tests. The degree of afobazole effect in a dose of 5 mg/kg (i.p.) is similar to that of the standard antidepressant amitriptyline administered in doses of 10 mg/kg. Data obtained are testifying to the antidepressant activity of afobazole.
摘要
在对远交系大鼠进行的实验中，抗焦虑药物阿福唑嗪在波索尔特和野村游泳试验中可减少不动时间。5毫克/千克（腹腔注射）剂量的阿福唑嗪的作用程度与10毫克/千克剂量的标准抗抑郁药阿米替林相似。所获数据证实了阿福唑嗪的抗抑郁活性。
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