Song Yuanhui, Song Gnanbin
College of Bioengineering, Chongqing University, Chongqing 400044, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Feb;26(1):195-8.
Stem cells are a kind of specialized cell type with the ability of self-renewal and multilineage differentiation potential. They can proliferate and differentiate into many other cell types under a specific condition. However, proliferation and differentiation behaviors of stem cells depend on their located microenvironment, which is also named stem cell niche. An appropriate spatiotemporal dialog occurs between stem cells and niche to fulfill the balance of their self-renewal and differentiation. This review focused on several different stem cell niches and their relationship with proliferation and differentiation of stem cells.
干细胞是一种具有自我更新能力和多谱系分化潜能的特殊细胞类型。在特定条件下，它们能够增殖并分化为许多其他细胞类型。然而，干细胞的增殖和分化行为取决于其所处的微环境，该微环境也被称为干细胞龛。干细胞与龛之间会发生适当的时空对话，以实现其自我更新和分化的平衡。本文综述聚焦于几种不同的干细胞龛及其与干细胞增殖和分化的关系。
