三法烷型倍半萜类化合物三法烷醇A和B的高效非对映选择性合成。
Efficient diastereoselective synthesis of trifarane-type sesquiterpenes, trifarienols A and B.
作者信息
Takahashi Kazunori, Akao Ryuichi, Honda Toshio
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
出版信息
J Org Chem. 2009 May 1;74(9):3424-9. doi: 10.1021/jo900369t.
PMID:19334700
Abstract
Diastereoselective total synthesis of trifarienols A and B, trifarane-type sesquiterpenes isolated from the Malaysian Cheilolejeunea trifaria, was achieved via an intramolecular Hosomi-Sakurai reaction of the aldehyde to construct a substituted bicyclo[3.3.1]nonane skeleton having the exo-methylene moiety of the target compounds in one step.
摘要
从马来西亚的三瓣唇鳞苔中分离得到的三瓣苔醇A和B（三瓣烷型倍半萜）的非对映选择性全合成，是通过醛的分子内保土谷-樱井反应一步构建具有目标化合物外亚甲基部分的取代双环[3.3.1]壬烷骨架来实现的。
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