Herráiz M, Muñoz-Navas M
Service of Digestive Diseases, Unit of Prevention and High-risk Gastrointestinal Cancer Clinic, Clínica Universidad de Navarra, Pamplona, Spain.
Rev Esp Enferm Dig. 2009 Feb;101(2):125-32. doi: 10.4321/s1130-01082009000200006.
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of individuals at-risk. Colonoscopy and prophylactic colectomy decrease colorectal cancer incidence and overall mortality in patients with hereditary colon cancer. Extracolonic tumors are frequent in these syndromes, so specific surveillance strategies should be offered.
2009年，西班牙将有超过1900例结直肠肿瘤与遗传性结直肠癌综合征相关联。近年来，已发现了导致最常见综合征的基因缺陷。基因检测有助于诊断患病个体，并能识别有风险的个体。结肠镜检查和预防性结肠切除术可降低遗传性结肠癌患者的结直肠癌发病率和总体死亡率。这些综合征中常出现结肠外肿瘤，因此应提供特定的监测策略。
