肝脏缺血再灌注损伤中的Toll样受体：治疗调控的新靶点？
Toll-like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation?
作者信息
Katsargyris Athanasios, Klonaris Chris, Alexandrou Andreas, Giakoustidis Alexander E, Vasileiou Ioanna, Theocharis Stamatios
机构信息
University of Athens, Athens, Greece.
出版信息
Expert Opin Ther Targets. 2009 Apr;13(4):427-42. doi: 10.1517/14728220902794939.
BACKGROUND
There is increasing evidence that Toll-like receptors (TLRs) sense host tissue damage by engaging with endogenous ligands. TLRs are considered to be involved in many primarily non-immune-related diseases. Hepatic ischemia reperfusion injury (IRI) represents one of these disorders.
OBJECTIVE
To present the latest findings supporting the involvement of TLRs in liver IRI and to explore their role as potential targets for therapeutic intervention.
METHODS
A review of the literature summarizing the latest advances in TLR signaling, the role of TLRs in each hepatic cell population and the involvement of TLRs in the pathophysiology of hepatic IRI. The potential role of TLR-targeting treatment strategies in liver IRI is discussed.
CONCLUSIONS
Recent experimental evidence suggests that TLR activation on Kupffer cells provides the triggering signal for pro-inflammatory responses that lead to liver IRI. Modulating TLR signaling could have a beneficial effect in patients with liver IRI.
背景
越来越多的证据表明，Toll样受体（TLRs）通过与内源性配体结合来感知宿主组织损伤。TLRs被认为参与了许多主要与非免疫相关的疾病。肝缺血再灌注损伤（IRI）就是其中之一。
目的
介绍支持TLRs参与肝IRI的最新研究结果，并探讨其作为治疗干预潜在靶点的作用。
方法
综述文献，总结TLR信号传导的最新进展、TLRs在各肝细胞群体中的作用以及TLRs在肝IRI病理生理学中的参与情况。讨论了针对TLR的治疗策略在肝IRI中的潜在作用。
结论
最近的实验证据表明，库普弗细胞上的TLR激活为导致肝IRI的促炎反应提供了触发信号。调节TLR信号传导可能对肝IRI患者有益。
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