Ryu Sung Jin, Park Sang Chul
Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Aging and Apoptosis Research Center, Seoul, South Korea.
Expert Opin Ther Targets. 2009 Apr;13(4):479-84. doi: 10.1517/14728220902832705.
Recent studies have shown that major vault protein (MVP) is involved in intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly responsible for nucleo-cytoplasmic drug transport in multi-drug-resistant cancer cell lines. Recently, we reported that MVP increases with age both in vitro and in vivo, and that age-related upregulation of MVP facilitates apoptosis resistance of senescent human diploid fibroblasts (HDFs) based on the interaction with c-Jun-mediated downregulation of bcl-2.
To discuss the role of MVP in cell survival and signaling in the development of resistance to apoptosis exhibited by senescent HDFs.
MVP represents a versatile platform for regulation of cellular signaling and survival and is a potential therapeutic target for modulation of resistance to apoptosis, implicated in aging modulation and cancer treatment.
最近的研究表明，主要穹窿蛋白（MVP）参与细胞内信号传导、细胞存活、分化和先天免疫，并且它并非多药耐药癌细胞系中核质药物转运的直接原因。最近，我们报道MVP在体外和体内均随年龄增长而增加，并且基于与c-Jun介导的bcl-2下调的相互作用，MVP的年龄相关上调促进了衰老的人二倍体成纤维细胞（HDFs）的抗凋亡能力。
探讨MVP在衰老HDFs表现出的细胞存活及抗凋亡信号传导中的作用。
MVP是调节细胞信号传导和存活的多功能平台，是调节抗凋亡能力的潜在治疗靶点，与衰老调节和癌症治疗有关。
