de Mendonça Adriana Cutrim, Santos Vanessa Renata, César-Neto João Batista, Duarte Poliana Mendes
Department of Periodontics, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
J Periodontol. 2009 Apr;80(4):693-9. doi: 10.1902/jop.2009.080521.
The aim of the present case series was to evaluate the effects of a surgical anti-infective mechanical therapy for peri-implantitis on clinical parameters and tumor necrosis factor-alpha (TNF-alpha) levels at 12 months post-therapy.
Ten patients with peri-implantitis were treated with open surgical debridement, abrasive sodium carbonate air-powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these time points, the total amounts of TNF-alpha in the peri-implant crevicular fluid were measured by enzyme-linked immunosorbent assay.
At 3 and 12 months, the anti-infective therapy resulted in significant improvements in all clinical parameters (P <0.05). Moreover, the total amount of TNF-alpha was significantly reduced at 3 and 12 months after therapy compared to baseline (P <0.05), paralleling the changes in mean probing depth and bleeding on probing.
The anti-infective mechanical therapy reduced the crevicular levels of TNF-alpha in sites affected by peri-implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters.
本病例系列的目的是评估一种用于种植体周围炎的外科抗感染机械治疗对治疗后12个月时临床参数和肿瘤坏死因子-α（TNF-α）水平的影响。
10例种植体周围炎患者接受了开放性外科清创术、碳酸氢钠喷砂和树脂刮治器治疗。在治疗前以及治疗后3个月和12个月记录临床参数。在这些时间点，通过酶联免疫吸附测定法测量种植体周围龈沟液中TNF-α的总量。
在3个月和12个月时，抗感染治疗使所有临床参数均有显著改善（P<0.05）。此外，与基线相比，治疗后3个月和12个月时TNF-α的总量显著降低（P<0.05），这与平均探诊深度和探诊出血的变化情况平行。
抗感染机械治疗在12个月的时间内降低了种植体周围炎患位点龈沟液中TNF-α的水平，并且这一现象与临床参数的改善相关。
