Piña-Oviedo Sergio, Del Valle Luis, Baquera-Heredia Javier, Ortiz-Hidalgo Carlos
Department of Neuroscience, Neuropathology Core, Temple University School of Medicine, Philadelphia, PA, USA.
J Peripher Nerv Syst. 2009 Mar;14(1):22-6. doi: 10.1111/j.1529-8027.2009.00202.x.
Renaut bodies are well-demarcated cylindrical (circular in cross section) hyaline structures attached to the inner layer of the perineurium that can be found in normal and pathological nerves of various animals and humans. They are composed of spidery fibroblasts and perineurial cells immersed in an extracellular matrix that contains randomly oriented collagen fibers and elastin precursors but not axons or Schwann cells. Frequently, they are associated with thickened subperineurial capillaries. As Renaut bodies are mainly located at sites of nerve compression, it is hypothesized they may act as 'protective cushions' for endoneurial components, and that they may be formed as a secondary reaction to trauma. Herein, we report the presence of Renaut bodies within numerous small dermal nerve trunks in an amputated finger. By immunohistochemistry, Renaut bodies expressed markers identical to those of perineurial cells (epithelial membrane antigen, Glut-1, and claudin-1), supporting the concept of a closely associated perineurial but not endoneurial origin. In addition, expression of hypoxia-inducible factor 1 alpha (which has been shown to increase Glut-1 transcription), neurofibromatosis 1 gene related product and NF-2, were also detected in these peripheral nerve structures.
雷诺体是界限分明的圆柱形（横截面为圆形）透明结构，附着于神经束膜内层，可见于各种动物和人类的正常及病理神经中。它们由蛛网状成纤维细胞和神经束膜细胞组成，浸于含有随机排列的胶原纤维和弹性蛋白前体的细胞外基质中，但不含轴突或施万细胞。它们常与增厚的神经束膜下毛细血管相关。由于雷诺体主要位于神经受压部位，因此推测它们可能作为神经内膜成分的“保护垫”，并且可能是作为对创伤的继发反应而形成。在此，我们报告在一截断指的众多小皮神经干内存在雷诺体。通过免疫组织化学，雷诺体表达的标志物与神经束膜细胞的标志物相同（上皮膜抗原、葡萄糖转运蛋白1和闭合蛋白1），支持其起源与神经束膜密切相关而非神经内膜的观点。此外，在这些周围神经结构中还检测到缺氧诱导因子1α（已证明其可增加葡萄糖转运蛋白1的转录）、神经纤维瘤病1基因相关产物和神经纤维瘤病2基因的表达。
