Jahns H, Fast C
Pathobiology Section, UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, Greifswald-Isle of Riems, Germany.
J Comp Pathol. 2014 Feb-Apr;150(2-3):234-44. doi: 10.1016/j.jcpa.2013.11.207. Epub 2013 Dec 1.
One hundred and sixty-eight ganglia from 54 cattle aged 10 days to 10 years were examined microscopically. Samples from six autonomic ganglia and one sensory ganglion were represented. Thirteen animals were clinically normal and 41 were submitted for post-mortem examination. Neuronal vacuolation, spheroid formation, lipofuscin accumulation and central chromatolysis were observed sporadically and were of varying magnitude. Neuronal vacuolation and spheroid formation were not age-related changes, while lipofuscin accumulation was more common in older animals and central chromatolysis was more common in younger cattle. Non-suppurative inflammation and neuronophagia were also common findings (23 out of 54 animals, 42.6%) in autonomic ganglia that did not contain herpesvirus DNA as determined by polymerase chain reaction. Renaut bodies, features of peripheral nerves, were most commonly noted in the vagus. None of the histopathological findings were related to any particular disease in which loss of autonomic nervous system function might be expected. Furthermore, all changes were as common in clinically normal animals as in animals with disease.
对54头年龄从10天至10岁的牛的168个神经节进行了显微镜检查。样本取自六个自主神经节和一个感觉神经节。13头动物临床正常，41头进行了尸检。偶见神经元空泡化、球体形成、脂褐素积聚和中央性染色质溶解，且程度各异。神经元空泡化和球体形成并非与年龄相关的变化，而脂褐素积聚在老年动物中更常见，中央性染色质溶解在幼年牛中更常见。非化脓性炎症和噬神经细胞现象也是自主神经节中的常见发现（54头动物中有23头，占42.6%），经聚合酶链反应测定，这些自主神经节不含疱疹病毒DNA。雷诺体，即外周神经的特征，最常见于迷走神经。组织病理学发现均与预期会出现自主神经系统功能丧失的任何特定疾病无关。此外，所有变化在临床正常动物和患病动物中同样常见。
