McDonald Scott A, Hutchinson Sharon J, Bird Sheila M, Graham Lesley, Robertson Chris, Mills Peter R, Hayes Peter, Dillon John F, Goldberg David J
Health Protection Scotland, Clifton House, Clifton Place, Glasgow, UK.
Addiction. 2009 Apr;104(4):593-602. doi: 10.1111/j.1360-0443.2009.02497.x.
To investigate the extent to which self-reported alcohol consumption level in the Scottish population is associated with first-time hospital admission for an alcohol-related cause.
Observational record-linkage study.
Scotland, 1995-2005.
A total of 23,183 respondents aged 16 and over who participated in the 1995, 1998 and 2003 Scottish Health Surveys, followed-up via record-linkage from interview date until 30 September 2005.
Rate of first-time hospital admission with at least one alcohol-related diagnosis. Cox proportional hazards regression analysis was applied to estimate the relative risk of first-time hospitalization with an alcohol-related condition associated with usual alcohol consumption level (1-7, 8-14, 15-21, 22-35, 36-49, 50+ units/week and ex-drinker, compared with <1 unit per week).
Of the SHS participants, 527 were hospitalized for an alcohol-related cause during 135,313 person-years of follow-up [39 first admissions per 10,000 person-years, 95% confidence interval (CI) 36-42]. Alcohol-related hospitalization rates were considerably higher for males (61/10,000 person-years, 95% CI 54-67) than for females (22/10,000 person-years, 95% CI 18-26). Compared with the lowest alcohol consumption category (<1 unit per week), the relative risk of first-time alcohol-related admission increased with reported consumption: age-adjusted hazard ratios ranged from 3 (1-5) for 1-7 units/week to 19 (10-37) for 50+ units/week (males); and from 2 (1-3) for 1-7 units/week to 28 (14-56) for 50+ units/week (females). After adjusting for age and usual alcohol consumption, the relative risk of first-time alcohol-related admission remained significantly higher for males reporting binge drinking and for both males and females residing in the most deprived localities.
Moderate and higher levels of usual alcohol consumption and binge drinking are serious risk factors for alcohol-related hospitalization in the Scottish population. These findings contribute to our understanding of the relationship between alcohol intake and alcohol-related morbidity.
调查苏格兰人群自我报告的饮酒量与首次因酒精相关原因住院之间的关联程度。
观察性记录链接研究。
苏格兰,1995 - 2005年。
共有23183名年龄在16岁及以上的受访者,他们参与了1995年、1998年和2003年的苏格兰健康调查,从访谈日期开始通过记录链接进行随访,直至2005年9月30日。
至少有一项酒精相关诊断的首次住院率。应用Cox比例风险回归分析来估计与通常饮酒量(每周1 - 7、8 - 14、15 - 21、22 - 35、36 - 49、50 +单位以及戒酒者,与每周<1单位相比)相关的首次因酒精相关疾病住院的相对风险。
在苏格兰健康调查的参与者中,在135313人年的随访期间,有527人因酒精相关原因住院[每10000人年39例首次住院,95%置信区间(CI)36 - 42]。男性的酒精相关住院率(每10000人年61例,95%CI 54 - 67)显著高于女性(每10000人年22例,95%CI 18 - 26)。与最低饮酒量类别(每周<1单位)相比,首次因酒精相关入院的相对风险随着报告的饮酒量增加而升高:年龄调整后的风险比范围从每周1 - 7单位的3(1 - 5)到每周50 +单位的19(10 - 37)(男性);以及从每周1 - 7单位的2(1 - 3)到每周50 +单位的28(14 - 56)(女性)。在调整年龄和通常饮酒量后,报告有暴饮行为的男性以及居住在最贫困地区的男性和女性首次因酒精相关入院的相对风险仍然显著更高。
适度及更高水平的通常饮酒量和暴饮是苏格兰人群酒精相关住院的严重风险因素。这些发现有助于我们理解酒精摄入量与酒精相关发病率之间的关系。