Wakabayashi Ichiro, Groschner Klaus
Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Clin Chim Acta. 2009 Jun 27;404(2):154-9. doi: 10.1016/j.cca.2009.03.047. Epub 2009 Mar 29.
Serum non-HDL cholesterol is a strong predictor of cardiovascular diseases. We studied the relationship between habitual alcohol drinking and non-HDL cholesterol.
Healthy male subjects (n = 27,005) and female subjects (n = 16,805) were divided into 5 groups by average daily ethanol intake. Serum non-HDL cholesterol level and prevalence of serum high non-HDL cholesterol (> or = 170 mg/dl) were compared among the groups.
Non-HDL cholesterol level and prevalence of high non-HDL cholesterol became lower as alcohol intake increased. The threshold alcohol intake in the drinker groups showing significantly lower non-HDL cholesterol level and significantly lower prevalence of high non-HDL cholesterol, compared with those in non-drinkers, was lower in women (<10 g/d) than in men (> or = 10 and <20 g/d). Odds ratios of each drinker group vs. the non-drinker group for high non-HDL cholesterol became lower as alcohol intake increased. The odds ratio of each drinker group vs. the non-drinker group for high non-HDL cholesterol tended to be lower in women than in men.
The results suggest that even light drinking is sufficient to significantly lower serum non-HDL cholesterol and that this effect of alcohol drinking on non-HDL cholesterol is more pronounced in women than in men.
血清非高密度脂蛋白胆固醇是心血管疾病的有力预测指标。我们研究了习惯性饮酒与非高密度脂蛋白胆固醇之间的关系。
健康男性受试者（n = 27,005）和女性受试者（n = 16,805）按平均每日乙醇摄入量分为5组。比较各组间血清非高密度脂蛋白胆固醇水平及血清高非高密度脂蛋白胆固醇（≥170 mg/dl）的患病率。
随着酒精摄入量增加，非高密度脂蛋白胆固醇水平及高非高密度脂蛋白胆固醇患病率降低。与不饮酒者相比，非高密度脂蛋白胆固醇水平显著降低且高非高密度脂蛋白胆固醇患病率显著降低的饮酒者组的酒精摄入阈值，女性（<10 g/d）低于男性（≥10且<20 g/d）。随着酒精摄入量增加，各饮酒者组与不饮酒者组相比，高非高密度脂蛋白胆固醇的优势比降低。各饮酒者组与不饮酒者组相比，高非高密度脂蛋白胆固醇的优势比女性往往低于男性。
结果表明，即使少量饮酒也足以显著降低血清非高密度脂蛋白胆固醇，且饮酒对非高密度脂蛋白胆固醇的这种影响在女性中比在男性中更明显。
