Song Jooeun, Fisher Beth E, Petzinger Giselle, Wu Allan, Gordon James, Salem George J
Musculoskeletal Biomechanics Research Laboratory, Division of Biokinesiology & Physical Therapy, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Neurorehabil Neural Repair. 2009 Sep;23(7):657-61. doi: 10.1177/1545968309332878. Epub 2009 Mar 31.
The Unified Parkinson's Disease Rating Scale (UPDRS) is the "gold standard" assessment tool for characterizing impairments in persons with Parkinson's disease (PD); however, this scale's ability to predict functional capabilities across different functional tasks has not been adequately assessed in persons with early-stage PD.
Thirty persons with PD within 3 years of diagnosis and without motor fluctuation performed self-selected walking, fast walking, and sit-to-stand and stair-climbing tasks. Pearson's correlation coefficients were used to calculate correlations with a standard UPDRS examination (P<.05). Simple linear regression models were used to fit each functional performance outcome measure with the UPDRS total predictor scores.
The correlations between the UPDRS motor (section III), UPDRS total scores, and all timed functional performance measures were fair to good (range, 0.45-0.57). Conversely, only greater self-selected time to walk 50 ft correlated with a higher UPDRS activities of daily living (II) score (r=.386; P<.05).
The UPDRS motor (III) and total scores may be good predictors of overall lower extremity function in persons with early-stage PD. Understanding the relationships between UPDRS scores and functional capabilities may allow clinicians to better quantify early physical functioning, longitudinally assess disease progression, and assess the efficacy of interventions.
统一帕金森病评定量表（UPDRS）是用于描述帕金森病（PD）患者损伤情况的“金标准”评估工具；然而，该量表预测不同功能任务中功能能力的能力在早期PD患者中尚未得到充分评估。
30名诊断后3年内且无运动波动的PD患者进行了自选步行、快速步行、从坐到站及爬楼梯任务。使用Pearson相关系数计算与标准UPDRS检查的相关性（P<0.05）。使用简单线性回归模型将每个功能表现结果测量值与UPDRS总预测得分进行拟合。
UPDRS运动部分（第三部分）、UPDRS总分与所有定时功能表现测量值之间的相关性为中等至良好（范围为0.45 - 0.57）。相反，只有更长的自选50英尺步行时间与更高的UPDRS日常生活活动部分（第二部分）得分相关（r = 0.386；P<0.05）。
UPDRS运动部分（第三部分）和总分可能是早期PD患者整体下肢功能的良好预测指标。了解UPDRS得分与功能能力之间的关系可能使临床医生能够更好地量化早期身体功能、纵向评估疾病进展并评估干预措施的疗效。
