Stebbins G T, Goetz C G
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
Mov Disord. 1998 Jul;13(4):633-6. doi: 10.1002/mds.870130404.
The Unified Parkinson's Disease Rating Scale (UPDRS) is widely used to assess Parkinson's disease (PD) disability but its metric properties have not been extensively studied. We investigated the factor structure and internal consistency of the Motor Examination section of the UPDRS in a sample of 294 consecutive patients with idiopathic PD who were assessed while in the "on" state. There was a high degree of internal consistency. Factor analysis revealed six clinically distinct factors, three bradykinesia measures (axial/gait, right and left), one rigidity measure, and two tremor measures (rest and postural). These factors accounted for 78% of the variance. Total Motor Examination scores and selected factors correlated well with other examiner-determined global ratings of PD disability (Hoehn and Yahr stage and Schwab-England Activities of Daily Living score). These results suggest that the Motor Examination section of the UPDRS provides a useful measure of PD function as well as severity measures of six clinical disability domains.
统一帕金森病评定量表（UPDRS）被广泛用于评估帕金森病（PD）的残疾程度，但其度量特性尚未得到广泛研究。我们在294例连续的特发性帕金森病患者样本中，对处于“开”状态时进行评估的UPDRS运动检查部分的因子结构和内部一致性进行了研究。内部一致性程度很高。因子分析揭示了六个临床上不同的因子，三个运动迟缓测量指标（轴向/步态、右侧和左侧），一个强直测量指标，以及两个震颤测量指标（静止性和姿势性）。这些因子解释了78%的方差。运动检查总分和选定因子与其他由检查者确定的帕金森病残疾总体评分（Hoehn和Yahr分期以及Schwab-England日常生活活动评分）相关性良好。这些结果表明，UPDRS的运动检查部分为帕金森病功能提供了一个有用的测量方法，以及六个临床残疾领域的严重程度测量方法。
