Hudson A J
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Can J Neurol Sci. 1991 Aug;18(3 Suppl):387-9. doi: 10.1017/s0317167100032509.
In a recent report on the clinical and pathological features of Guamanian ALS/PD and post-encephalitic parkinsonism/ALS a number of similarities were described, notably in the distribution of neurofibrillary tangles throughout the nervous system. In this account additional pathological features which these disorders share (and which differ from classical ALS, Parkinson's and Alzheimer's diseases) are described. These include atrophy of the globus pallidus and the entire substantia nigra, viz. pars compacta and pars reticulata. Moreover, neither Lewy bodies nor senile plaques are features of the Guamanian and post-encephalitic disorders. The significance of these observations and their relationship, more generally, to parkinsonism, ALS and dementia are discussed.
在最近一份关于关岛肌萎缩侧索硬化症/帕金森病以及脑炎后帕金森综合征/肌萎缩侧索硬化症临床与病理特征的报告中，描述了一些相似之处，尤其是神经原纤维缠结在整个神经系统中的分布情况。在本报告中，还描述了这些疾病共有的（且不同于经典肌萎缩侧索硬化症、帕金森病和阿尔茨海默病的）其他病理特征。这些特征包括苍白球和整个黑质萎缩，即致密部和网状部。此外，路易小体和老年斑都不是关岛疾病和脑炎后疾病的特征。本文讨论了这些观察结果的意义，以及它们更普遍地与帕金森综合征、肌萎缩侧索硬化症和痴呆症之间的关系。
