草珊瑚的三种新型倍半萜糖苷。

Three novel sesquiterpene glycosides of Sarcandra glabra.

作者信息

Hu Xiao-ru, Yang Jun-shan, Xu Xu-dong

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2009 Apr;57(4):418-20. doi: 10.1248/cpb.57.418.

DOI:10.1248/cpb.57.418

PMID:19336941

Abstract

Three new sesquiterpene glycosides, 8 beta,9 beta-epoxy-4 alpha-hydroxy-5 alpha H-lindan-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (1, sarcaglaboside F), 4 alpha-hydroxy-5 alpha,8 beta H-lindan-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (2, sarcaglaboside G), 4 alpha-hydroxy-5 alpha,8 beta H-eudesman-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (3, sarcaglaboside H), together with five known compounds, chloranoside A (4), sarcaglaboside C (5), dihydrovomifoliol-O-beta-D-glucopyranoside (6), 9-hydroxy-heterogorgiolide (7) and chloranthalactone B (8), were isolated from Sarcandra glabra THUMB. NAKAI. The structures and relative configurations of three new compounds were determined on the basis of their spectroscopic data and chemical evidence.

摘要

从草珊瑚（Sarcandra glabra THUMB. NAKAI）中分离得到了三种新的倍半萜糖苷，即8β,9β-环氧-4α-羟基-5αH-榄香-7(11)-烯-8α,12-内酯-15-O-β-D-吡喃葡萄糖苷（1，草珊瑚苷F）、4α-羟基-5α,8βH-榄香-7(11)-烯-8α,12-内酯-15-O-β-D-吡喃葡萄糖苷（2，草珊瑚苷G）、4α-羟基-5α,8βH-桉叶-7(11)-烯-8α,12-内酯-15-O-β-D-吡喃葡萄糖苷（3，草珊瑚苷H），以及五种已知化合物，氯珊瑚苷A（4）、草珊瑚苷C（5）、二氢vomifoliol-O-β-D-吡喃葡萄糖苷（6）、9-羟基-异海松内酯（7）和金粟兰内酯B（8）。根据三种新化合物的光谱数据和化学证据确定了其结构和相对构型。