草珊瑚中的保肝倍半萜糖苷

Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.

作者信息

Li Yuan, Zhang Dong-Ming, Li Jian-Bei, Yu Shi-Shan, Li Yan, Luo Yong-Ming

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2006 Apr;69(4):616-20. doi: 10.1021/np050480d.

DOI:10.1021/np050480d

PMID:16643038

Abstract

Six new sesquiterpene glycosides, compounds 1-6, with eudesmanolide, elemanolide, lindenane, and germacranolide sesquiterpene aglycons, along with one known compound, chloranoside A (7), have been isolated from the whole plant of Sarcandra glabra. The structures of 1-6 were elucidated by chemical and spectroscopic methods including (1)H-(1)H COSY, HMQC, HMBC, and NOESY NMR experiments. In addition, compounds 1-7 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.

摘要

从肿节风全株中分离出了六种新的倍半萜糖苷化合物1-6，其苷元分别为桉叶烷型、榄香烷型、indenane型和吉马烷型倍半萜，还分离出了一种已知化合物氯冉糖苷A（7）。通过化学和光谱方法，包括1H-1H COSY、HMQC、HMBC和NOESY核磁共振实验，阐明了化合物1-6的结构。此外，化合物1-7对D-半乳糖胺诱导的WB-F344大鼠肝上皮干细胞样细胞毒性表现出显著的肝保护活性。