Ye Qing-Song, Xie Ming-Jin, Liu Wei-Ping, Chen Xi-Zhu, Yu Yao, Chang Qiao-Wen, Hou Shu-Qian
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China.
Chem Pharm Bull (Tokyo). 2009 Apr;57(4):424-7. doi: 10.1248/cpb.57.424.
Diiodo-, dibromo- and dichloro-platinum(II) complexes containing L-histidine ligand were prepared. Their spectra and X-ray crystal structure of the dibromo-platinum(II) complex were described. Only the dichloro-platinum(II) complex showed comparable cytotoxic activity with carboplatin against A549/ATCC, HT-29, and LNcap cell lines. Nevertheless the complexes with COOH-substituted ligands histidine may be good starting materials to synthesize targeting platinum complexes since they could be easily linked to suitable carrier molecules via esterification.
制备了含有L-组氨酸配体的二碘、二溴和二氯铂（II）配合物。描述了二溴铂（II）配合物的光谱和X射线晶体结构。只有二氯铂（II）配合物对A549/ATCC、HT-29和LNcap细胞系显示出与卡铂相当的细胞毒性活性。然而，具有COOH取代配体组氨酸的配合物可能是合成靶向铂配合物的良好起始材料，因为它们可以通过酯化容易地与合适的载体分子连接。
