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新型氯碘羟喹及其类似物铂配合物：重要性、卤代取代和配体羟基的作用。

Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand.

机构信息

Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.

出版信息

Dalton Trans. 2013 Oct 7;42(37):13343-8. doi: 10.1039/c3dt51720a. Epub 2013 Aug 14.

DOI:10.1039/c3dt51720a
PMID:23945635
Abstract

In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate the importance and the role of the halogen substitution as well as the chelation, which are essential structural characteristics for finding good cytotoxicities.

摘要

在本通讯中，我们展示了基于羟基喹啉配体的新型铂配合物的合成。我们证明了卤素取代以及螯合的重要性和作用，这是发现良好细胞毒性的必要结构特征。

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