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Low-dose flutamide for women with androgen excess: anti-androgenic efficacy and hepatic safety.

作者信息

de Zegher F, Ibáñez L

机构信息

Department of Woman & Child, University of Leuven, Leuven, Belgium.

出版信息

J Endocrinol Invest. 2009 Jan;32(1):83-4. doi: 10.1007/BF03345685.

DOI:10.1007/BF03345685
PMID:19337022
Abstract
摘要

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Randomized clinical trial: effect of low-dose flutamide on abdominal adipogenic function in normal-weight women with polycystic ovary syndrome.随机临床试验：低剂量氟他胺对正常体重多囊卵巢综合征女性腹部脂肪生成功能的影响。
Fertil Steril. 2023 Jan;119(1):116-126. doi: 10.1016/j.fertnstert.2022.09.324. Epub 2022 Nov 15.

本文引用的文献

1
The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism.
Arch Gynecol Obstet. 2009 Mar;279(3):321-7. doi: 10.1007/s00404-008-0719-z. Epub 2008 Jul 8.
2
Long-term safety and tolerability of flutamide for the treatment of hirsutism.
Fertil Steril. 2009 Apr;91(4):1183-8. doi: 10.1016/j.fertnstert.2008.01.046. Epub 2008 Mar 12.
3
Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline.绝经前女性多毛症的评估与治疗：内分泌学会临床实践指南
J Clin Endocrinol Metab. 2008 Apr;93(4):1105-20. doi: 10.1210/jc.2007-2437. Epub 2008 Feb 5.
4
Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin.吡格列酮（7.5 毫克/天）添加到雄激素过多的女性中富马酸二甲酯-二甲双胍：内脂素和高分子量脂联素的额外增加。
Clin Endocrinol (Oxf). 2008 Feb;68(2):317-20. doi: 10.1111/j.1365-2265.2007.03137.x. Epub 2007 Nov 19.
5
Persisting benefits 12-18 months after discontinuation of pubertal metformin therapy in low birthweight girls.在低出生体重女孩中，青春期二甲双胍治疗停药后 12-18 个月仍持续获益。
Clin Endocrinol (Oxf). 2007 Sep;67(3):468-71. doi: 10.1111/j.1365-2265.2007.02952.x. Epub 2007 Jul 2.
6
Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial.
J Clin Endocrinol Metab. 2007 Sep;92(9):3446-52. doi: 10.1210/jc.2006-2798. Epub 2007 Jun 12.
7
Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess.低剂量吡格列酮、氟他胺和二甲双胍联合治疗雄激素过多的女性。
J Clin Endocrinol Metab. 2007 May;92(5):1710-4. doi: 10.1210/jc.2006-2684. Epub 2007 Feb 13.
8
Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study.在超重肥胖的多囊卵巢综合征女性中，使用氟他胺、二甲双胍及其联合用药并结合低热量饮食进行治疗：一项为期12个月的随机、安慰剂对照研究。
J Clin Endocrinol Metab. 2006 Oct;91(10):3970-80. doi: 10.1210/jc.2005-2250. Epub 2006 Jul 25.
9
Fatal liver complications with flutamide.氟他胺导致的致命性肝脏并发症。
Lancet. 2006 Apr 8;367(9517):1140-1. doi: 10.1016/S0140-6736(06)68498-5.
10
Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women.低剂量氟他胺-二甲双胍疗法治疗非肥胖青少年和女性的高胰岛素血症性高雄激素血症
Hum Reprod Update. 2006 May-Jun;12(3):243-52. doi: 10.1093/humupd/dmi054. Epub 2006 Jan 11.