腺苷激酶（AK）和腺嘌呤磷酸核糖转移酶（APRT）缺陷的WI-L2人淋巴母细胞系突变体中的嘌呤合成与排泄 - Suppr | 超能文献

Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT).

作者信息

Hershfield M S, Spector E B, Seegmiller J E

出版信息

Adv Exp Med Biol. 1977;76A:303-13. doi: 10.1007/978-1-4613-4223-6_38.

DOI:10.1007/978-1-4613-4223-6_38

Abstract

摘要

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1

Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT).腺苷激酶（AK）和腺嘌呤磷酸核糖转移酶（APRT）缺陷的WI-L2人淋巴母细胞系突变体中的嘌呤合成与排泄

Adv Exp Med Biol. 1977;76A:303-13. doi: 10.1007/978-1-4613-4223-6_38.

2

Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.腺嘌呤和腺苷对嘌呤补救酶有缺陷的人类淋巴母细胞突变体有毒性。

Science. 1977 Sep 23;197(4310):1284-7. doi: 10.1126/science.197600.

3

Purine reutilization and synthesis de novo in APRT deficient long-term lymphocyte lines.

Monogr Hum Genet. 1978;10:108-11. doi: 10.1159/000401577.

4

Purine reutilization and synthesis de novo in long-term human lymphocyte cell lines deficient in adenine phosphoribosyltransferase activity.腺嘌呤磷酸核糖转移酶活性缺陷的长期人类淋巴细胞系中的嘌呤再利用和从头合成

Somatic Cell Genet. 1978 May;4(3):253-64. doi: 10.1007/BF01542842.

5

Purine toxicity in human lymphoblasts.

Adv Exp Med Biol. 1977;76A:30-9. doi: 10.1007/978-1-4613-4223-6_4.

6

Coordinate regulation of the proximal and distal steps of the pathway of purine synthesis de nono in WI-L2 human lymphoblasts.WI-L2人淋巴母细胞中嘌呤从头合成途径近端和远端步骤的协调调节。

Adv Exp Med Biol. 1977;76A:19-29. doi: 10.1007/978-1-4613-4223-6_3.

7

Elucidation of aberrant purine metabolism: application to hypoxanthine-guanine phosphoribosylstransferase- and adenosine kinase-deficient mutants, and IMP dehydrogenase- and adenosine deaminase-inhibited human lymphoblasts.异常嘌呤代谢的阐明：应用于次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶和腺苷激酶缺陷型突变体，以及肌苷酸脱氢酶和腺苷脱氨酶抑制的人淋巴母细胞。

Biochim Biophys Acta. 1980 Oct 17;609(3):492-501. doi: 10.1016/0005-2787(80)90123-9.

8

Glial cells metabolically cooperate: a potential requirement for gene replacement therapy.神经胶质细胞代谢协同作用：基因替代疗法的潜在需求。

Proc Natl Acad Sci U S A. 1985 Oct;82(19):6662-6. doi: 10.1073/pnas.82.19.6662.

9

Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

J Biol Chem. 1977 Sep 10;252(17):6002-10.

10

Screening for adenine and hypoxanthine phosphoribosyltransferase deficiencies in human erythrocytes by high-performance liquid chromatography.通过高效液相色谱法筛查人类红细胞中的腺嘌呤和次黄嘌呤磷酸核糖基转移酶缺陷。

Clin Chim Acta. 1987 Dec;170(2-3):281-9. doi: 10.1016/0009-8981(87)90138-0.

引用本文的文献

1

Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.腺苷激酶缺陷型人淋巴母细胞系对脱氧腺苷在生长、S-腺苷同型半胱氨酸水解酶失活及dATP积累方面作用的抗性。

Proc Natl Acad Sci U S A. 1980 Jul;77(7):4292-6. doi: 10.1073/pnas.77.7.4292.

2

Overproduction of uric acid in hypoxanthine-guanine phosphoribosyltransferase deficiency. Contribution by impaired purine salvage.次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶缺乏症中尿酸的过度产生。嘌呤补救途径受损的影响。

J Clin Invest. 1979 May;63(5):922-30. doi: 10.1172/JCI109392.