PAIII前列腺肿瘤在Lobund-Wistar大鼠中表达前列腺特异性抗原（PSA）。
PAIII prostate tumors express prostate specific antigen (PSA) in Lobund-Wistar rats.
作者信息
Suckow Mark A, Wheeler James, Yan Min
机构信息
Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
出版信息
Can J Vet Res. 2009 Jan;73(1):39-41.
Prostate cancer has been modeled in various species, including dogs, mice, and rats. A common method involves the use of transplanted prostate cancer cell lines. The Lobund-Wistar (LW) rat model of prostate cancer allows for the use of models involving either autochthonous prostate cancer or transplantation of a cell line (PAIII), originally derived from a LW rat. The origin of autochthonous prostate tumors in the LW rat is unknown, though suspected to originate from the seminal vesicles. Likewise, the prostatic origin of the PAIII cell line is also uncertain. To determine if the PAIII cell line is derived from the prostate, subcutaneous PAIII tumors from LW rats underwent immunohistochemical labeling for prostate specific antigen (PSA), a prostate-specific serine protease. All 5 PAIII tumors demonstrated labeling for PSA, supporting a prostatic origin for the PAIII cell line.
前列腺癌已在包括狗、小鼠和大鼠在内的多种物种中建立了模型。一种常见的方法是使用移植的前列腺癌细胞系。Lobund-Wistar（LW）大鼠前列腺癌模型允许使用涉及原位前列腺癌或细胞系（PAIII）移植的模型，该细胞系最初来源于LW大鼠。尽管怀疑原位前列腺肿瘤起源于精囊，但LW大鼠原位前列腺肿瘤的起源尚不清楚。同样，PAIII细胞系的前列腺起源也不确定。为了确定PAIII细胞系是否来源于前列腺，对LW大鼠皮下PAIII肿瘤进行了前列腺特异性抗原（PSA，一种前列腺特异性丝氨酸蛋白酶）的免疫组织化学标记。所有5个PAIII肿瘤均显示PSA标记，支持PAIII细胞系来源于前列腺。
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