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本文引用的文献

1
Development of the retinal vasculature.视网膜血管系统的发育。
Angiogenesis. 2007;10(2):77-88. doi: 10.1007/s10456-007-9065-1. Epub 2007 Feb 24.
2
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.Notch配体Delta样蛋白4负向调节内皮尖端细胞形成和血管分支。
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3225-30. doi: 10.1073/pnas.0611177104. Epub 2007 Feb 12.
3
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.Delta样配体4（Dll4）由血管内皮生长因子（VEGF）诱导产生，作为血管生成芽的负调节因子。
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3219-24. doi: 10.1073/pnas.0611206104. Epub 2007 Feb 12.
4
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.通过Notch1的Dll4信号传导在血管生成过程中调节顶端细胞的形成。
Nature. 2007 Feb 15;445(7129):776-80. doi: 10.1038/nature05571. Epub 2007 Jan 28.
5
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries.Notch信号通路限制斑马鱼发育中动脉血管生成细胞的行为。
Nature. 2007 Feb 15;445(7129):781-4. doi: 10.1038/nature05577. Epub 2007 Jan 28.
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Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.Notch配体Delta样蛋白4介导的内皮信号传导限制血管生成。
Development. 2007 Mar;134(5):839-44. doi: 10.1242/dev.003244. Epub 2007 Jan 24.
7
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.抑制Dll4信号传导可通过解除血管生成的调控来抑制肿瘤生长。
Nature. 2006 Dec 21;444(7122):1083-7. doi: 10.1038/nature05313.
8
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.抑制Dll4可通过促进无效血管生成来抑制肿瘤生长。
Nature. 2006 Dec 21;444(7122):1032-7. doi: 10.1038/nature05355.
9
Notch signaling pathway.Notch信号通路。
Sci STKE. 2006 Dec 5;2006(364):cm7. doi: 10.1126/stke.3642006cm7.
10
Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation.在血管形成过程中，内皮细胞分裂的方向受血管内皮生长因子（VEGF）信号调控。
Blood. 2007 Feb 15;109(4):1345-52. doi: 10.1182/blood-2006-07-037952. Epub 2006 Oct 26.

血管内皮生长因子与血管生成芽生中的血管内皮导向。

VEGF and endothelial guidance in angiogenic sprouting.

机构信息

Vascular Biology Laboratory; London Research Institute; Cancer Research UK; Lincoln's Inn Fields Laboratories; London UK.

出版信息

Organogenesis. 2008 Oct;4(4):241-6. doi: 10.4161/org.4.4.7414.

DOI:10.4161/org.4.4.7414
PMID:19337404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2634329/
Abstract

The cellular actions of VEGF need to be coordinated to guide vascular patterning during sprouting angiogenesis. Individual endothelial tip cells lead and guide the blood vessel sprout, while neighbouring stalk cells proliferate and form the vascular lumen. Recent studies illustrate how endothelial DLL4/NOTCH signalling, stimulated by VEGF, regulates the sprouting response by limiting tip cell formation in the stalk. The spatial distribution of VEGF, in turn, regulates the shape of the ensuing sprout by directing tip cell migration and determining stalk cell proliferation.

摘要

VEGF 的细胞作用需要协调，以指导发芽血管生成过程中的血管模式形成。单个内皮细胞尖端细胞引导并引导血管芽的生长，而相邻的茎细胞则增殖并形成血管腔。最近的研究说明了内皮 DLL4/NOTCH 信号如何通过限制茎中的尖端细胞形成来调节发芽反应，该信号受 VEGF 刺激。反过来，VEGF 的空间分布通过指导尖端细胞迁移和确定茎细胞增殖来调节随后的芽的形状。