血管内皮生长因子与血管生成芽生中的血管内皮导向。
VEGF and endothelial guidance in angiogenic sprouting.
机构信息
Vascular Biology Laboratory; London Research Institute; Cancer Research UK; Lincoln's Inn Fields Laboratories; London UK.
出版信息
Organogenesis. 2008 Oct;4(4):241-6. doi: 10.4161/org.4.4.7414.
Abstract
The cellular actions of VEGF need to be coordinated to guide vascular patterning during sprouting angiogenesis. Individual endothelial tip cells lead and guide the blood vessel sprout, while neighbouring stalk cells proliferate and form the vascular lumen. Recent studies illustrate how endothelial DLL4/NOTCH signalling, stimulated by VEGF, regulates the sprouting response by limiting tip cell formation in the stalk. The spatial distribution of VEGF, in turn, regulates the shape of the ensuing sprout by directing tip cell migration and determining stalk cell proliferation.
摘要
VEGF 的细胞作用需要协调，以指导发芽血管生成过程中的血管模式形成。单个内皮细胞尖端细胞引导并引导血管芽的生长，而相邻的茎细胞则增殖并形成血管腔。最近的研究说明了内皮 DLL4/NOTCH 信号如何通过限制茎中的尖端细胞形成来调节发芽反应，该信号受 VEGF 刺激。反过来，VEGF 的空间分布通过指导尖端细胞迁移和确定茎细胞增殖来调节随后的芽的形状。
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