Ahirwar Lalit K, Blackburn Spiros L, McBride Devin W, T Peeyush Kumar
The Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA.
Mol Psychiatry. 2025 Sep 2. doi: 10.1038/s41380-025-03200-z.
During cortical development, newly born neurons migrate radially or tangentially from their origin to expand the cortex. Simultaneously, neuron-derived factors support angiogenesis, and an elaborate network of blood cerebral vessels develops in the cortex. Traditionally, blood cerebral vessels were considered to support the growing cortex or migrating neurons by providing nutrients and oxygen. However, recent studies have shed light on Endothelial cells' influence on cortical development; they guide neuronal migration by providing molecular cues and structural support. Here, we review the current understanding of how CNS cerebral vessels support neurogenesis, neuronal migration, and the formation of the six-layer cortical structure during development. Additionally, we explore current knowledge regarding the vascular role in neurodevelopmental disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia.
在皮质发育过程中，新生成的神经元从其起源处沿径向或切向迁移，以扩展皮质。同时，神经元衍生因子支持血管生成，皮质中形成了精细的脑血管网络。传统上，脑血管被认为是通过提供营养和氧气来支持不断生长的皮质或迁移的神经元。然而，最近的研究揭示了内皮细胞对皮质发育的影响；它们通过提供分子线索和结构支持来引导神经元迁移。在这里，我们综述了目前对中枢神经系统脑血管在发育过程中如何支持神经发生、神经元迁移以及六层皮质结构形成的理解。此外，我们探讨了目前关于血管在神经发育障碍（包括自闭症谱系障碍、注意力缺陷多动障碍和精神分裂症）中作用的知识。
