Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR, USA.
Ther Clin Risk Manag. 2008 Dec;4(6):1343-58. doi: 10.2147/tcrm.s4328.
Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mechanisms provided by the colonic microbial ecosystem, making the host vulnerable to infection by commensal microorganisms or nosocomial pathogens. In this minireview, the impacts of antimicrobials, individually and in combinations, on the human colonic microflora are discussed.
抗菌药物是治疗细菌感染最有价值的手段。然而，给患者使用治疗剂量的抗菌药物是导致正常胃肠道微生物区系紊乱的主要原因。这种紊乱导致结肠微生物生态系统提供的天然防御机制减弱，使宿主易受共生微生物或医院病原体的感染。在这篇综述中，讨论了抗菌药物单独和联合使用对人类结肠微生物群的影响。
