Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, 575 Elmwood Ave., Box EHSC, Rochester, NY, USA.
Neuropsychiatr Dis Treat. 2008 Dec;4(6):1193-201. doi: 10.2147/ndt.s3257.
Fibromyalgia (FM) is a common, chronic pain disorder with unknown etiology, characterized by widespread musculoskeletal pain and tenderness, and accompanied by several other symptoms such as sleep disturbance, fatigue, and mood disorders. Pregabalin is the first drug approved for the treatment of FM. Pregabalin has analgesic, anticonvulsant, and anxiolytic activity and has earlier demonstrated efficacy in the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjuvant therapy for adult patients with partial onset seizures. Pregabalin, a lipophilic gamma-aminobutyric acid (GABA) analog, is alpha(2)delta-1 ligand that binds to, and modulates, voltage-gated calcium channels. This modulation is characterized by a reduction of the excessive neurotransmitter release that is observed in certain neurological and psychotic disorders. Several randomized, double-blind, placebo-controlled studies have demonstrated that pregabalin has been effective in pain management, improving sleep quality and fatigue, as well as in several domains of health related quality of life. Because of mild to moderate adverse effects it can be considered a well-tolerated therapy for FM.
纤维肌痛（FM）是一种常见的慢性疼痛障碍，病因不明，其特征为广泛的肌肉骨骼疼痛和压痛，并伴有其他几种症状，如睡眠障碍、疲劳和情绪障碍。普瑞巴林是第一种被批准用于治疗 FM 的药物。普瑞巴林具有镇痛、抗惊厥和抗焦虑作用，并且在治疗与糖尿病周围神经病变、带状疱疹后神经痛相关的神经性疼痛以及作为辅助治疗成人部分发作性癫痫方面早期已显示出疗效。普瑞巴林是一种亲脂性 γ-氨基丁酸（GABA）类似物，是一种α（2）δ-1 配体，与电压门控钙通道结合并调节其功能。这种调节的特点是减少在某些神经和精神疾病中观察到的过度神经递质释放。几项随机、双盲、安慰剂对照研究表明，普瑞巴林在疼痛管理、改善睡眠质量和疲劳以及健康相关生活质量的几个领域都有效。由于其轻度至中度的不良反应，它可以被认为是一种对 FM 耐受性良好的治疗方法。
