卵巢癌转移模型：小鼠模型。
Models of ovarian cancer metastasis: Murine models.
作者信息
Sale Sanja, Orsulic Sandra
机构信息
Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY7, Charlestown, MA 02129, United States.
出版信息
Drug Discov Today Dis Models. 2006 Jun 1;3(2):149-154. doi: 10.1016/j.ddmod.2006.05.006.
Abstract
Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical trials, however, the genetic complexity of human tumors has precluded the understanding of key events that drive metastatic dissemination. Recently developed immunocompetent, genetically defined mouse models of epithelial ovarian cancer represent significant improvements in the modeling of metastatic disease.
摘要
小鼠主要被用作卵巢癌研究中免疫缺陷宿主，用于培养源自卵巢癌患者原发性肿瘤和腹水的细胞系。这些异种移植模型为临床前试验提供了一个有价值的系统，然而，人类肿瘤的遗传复杂性阻碍了对驱动转移扩散关键事件的理解。最近开发的具有免疫活性、基因明确的上皮性卵巢癌小鼠模型在转移性疾病建模方面有了显著改进。
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