Thümmler K, Ramming A, Schulze-Koops H, Skapenko A
Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstrasse 8a, Munich, Germany.
Z Rheumatol. 2009 Jun;68(4):337-9. doi: 10.1007/s00393-009-0458-y.
In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.
除了天然胸腺来源的调节性T细胞（Tregs）外，外周诱导的Tregs在免疫稳态中也至关重要。活化的效应T细胞与静止记忆T细胞之间的同型相互作用在体外诱导产生了分泌白细胞介素-10（IL-10）和γ干扰素（IFNγ）的Tregs。Treg发育中的这一机制为T细胞疫苗接种提供了新的见解，T细胞疫苗接种已在多发性硬化症和类风湿性关节炎的试点试验中应用并取得了有前景的结果。
