T细胞疫苗接种中的调节性T细胞：探索调节的调控机制
Tregs in T cell vaccination: exploring the regulation of regulation.
作者信息
Cohen Irun R, Quintana Francisco J, Mimran Avishai
机构信息
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
出版信息
J Clin Invest. 2004 Nov;114(9):1227-32. doi: 10.1172/JCI23396.
Abstract
T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4+ and CD8+ Tregs have been described in detail. Here we shall focus on anti-erg T regulators. Anti-erg T cells, unlike anti-id T cells, do not recognize the clonal identity of effector T cells; rather, anti-erg T cells recognize the state of activation of target effector T cells, irrespective of their TCR specificity. We consider several features of anti-erg T cells: their ontogeny, subset markers, and target ergotope molecules; mechanisms by which they regulate other T cells; mechanisms by which they get regulated; and therapeutic prospects for anti-erg upregulation and downregulation.
摘要
T细胞疫苗接种（TCV）可激活两种调节性T细胞（Tregs）：抗独特型（抗id）和抗效应型（抗erg）。这些调节细胞为免疫反应中T细胞调节的生理学提供了一个有用的视角。抗id Tregs通过其独特的TCR CDR3肽识别特定的效应克隆；CD4+和CD8+ Tregs的抗id网络已得到详细描述。在此，我们将重点关注抗erg T调节细胞。与抗id T细胞不同，抗erg T细胞不识别效应T细胞的克隆身份；相反，抗erg T细胞识别靶效应T细胞的激活状态，而不考虑其TCR特异性。我们将探讨抗erg T细胞的几个特征：它们的个体发生、亚群标志物和靶效应表位分子；它们调节其他T细胞的机制；它们自身被调节的机制；以及抗erg上调和下调的治疗前景。
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