Andersen L J, Therkildsen M H, Ockelmann H H, Bentzen J D, Schiødt T, Hansen H S
Department of Head and Neck Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Cancer. 1991 Dec 1;68(11):2431-7. doi: 10.1002/1097-0142(19911201)68:11<2431::aid-cncr2820681118>3.0.co;2-n.
Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, followed by adenocarcinoma. The submandibular gland was the most frequent location. Five-year and 10-year crude survival rates were 62% and 43%, respectively. Clinical stage was the most important prognostic factor. Survival was not correlated with location of tumor, although recurrence and metastases occurred more frequently in patients with cancer of the submandibular gland. Histologically, the 5-year and 10-year survival was significantly better for patients with adenoid cystic carcinoma compared with the other types; however, although still significant, this difference diminished at 10 years, confirming the need for a long observation time for patients with this tumor.
回顾了25年间在颌下腺、舌下腺和小唾液腺发现的95例恶性肿瘤。采用国际抗癌联盟（UICC）分类法对患者进行回顾性分期。最常见的肿瘤是腺样囊性癌，其次是腺癌。颌下腺是最常见的发病部位。5年和10年的粗生存率分别为62%和43%。临床分期是最重要的预后因素。生存率与肿瘤位置无关，尽管颌下腺癌患者的复发和转移更为频繁。组织学上，腺样囊性癌患者的5年和10年生存率明显优于其他类型；然而，尽管这种差异仍然显著，但在10年时有所减小，这证实了对该肿瘤患者需要进行长时间观察。
