Poppelreuter M, Weis J, Bartsch H H
Tumor Biology Center, Institute for Rehabilitation Research, Freiburg, Germany.
J Psychosoc Oncol. 2009;27(2):274-96. doi: 10.1080/07347330902776044.
Neuropsychological deficits are among the negative side effects of adjuvant chemotherapy for breast cancer. We compared the effects of two types of neuropsychological interventions against a control group with no specific training in a total of 96 female in-patients undergoing oncological rehabilitation. Most results of a comprehensive neuropsychological test battery improved significantly during the patients' oncological rehabilitation in all three groups; we identified no specific intervention effects. We observed little overall correlation between the neuropsychological test results and the patients' own appraisals of their mental capacity. Clinically relevant neuropsychological deficits were still evident 6 months later in a small subgroup of patients.
神经心理缺陷是乳腺癌辅助化疗的负面副作用之一。我们将两种神经心理干预措施的效果与未接受特定训练的对照组进行了比较，共有96名接受肿瘤康复治疗的女性住院患者参与。在所有三组患者的肿瘤康复过程中，一套全面的神经心理测试的大多数结果都有显著改善；我们未发现特定的干预效果。我们观察到神经心理测试结果与患者对自身心理能力的评估之间总体相关性不大。6个月后，一小部分患者仍存在临床相关的神经心理缺陷。
