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乳腺癌患者化疗引起的前瞻性记忆障碍。

Chemotherapy-induced prospective memory impairment in patients with breast cancer.

作者信息

Cheng Huaidong, Yang Zhen, Dong Biao, Chen Chanjuan, Zhang Mingjun, Huang Zhonglian, Chen Zhendong, Wang Kai

机构信息

Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Neuropsychological Laboratory, Institute of Neurology and Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

出版信息

Psychooncology. 2013 Oct;22(10):2391-5. doi: 10.1002/pon.3291. Epub 2013 May 15.

DOI:10.1002/pon.3291

PMID:23674402

Abstract

OBJECTIVE

This study aimed to investigate the event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in chemotherapy-induced cognitive impairment in patients with breast cancer.

METHODS

Forty patients with breast cancer who underwent adjuvant chemotherapy and 40 age-matched and education-matched healthy women were administered with a battery of neuropsychological tests including EBPM and TBPM tasks.

RESULTS

A significant difference between breast cancer patients and controls was found in the scores on the mini-mental state examination (t = -11.684, p < 0.01), verbal fluency test (t = -7.939, p < 0.01), and digit span (t = -2.538, p < 0.05). Compared with healthy controls, breast cancer patients exhibited a poorer performance on EBPM (t = -7.096, p < 0.01) but not on TBPM (t = -1.921, p > 0.05).

CONCLUSIONS

Our results suggest that breast cancer patients who had undergone adjuvant chemotherapy show deficits in EBPM but not in TBPM.

摘要

目的

本研究旨在调查乳腺癌患者化疗引起的认知障碍中的基于事件的前瞻性记忆（EBPM）和基于时间的前瞻性记忆（TBPM）。

方法

对40例接受辅助化疗的乳腺癌患者和40例年龄及教育程度匹配的健康女性进行了一系列神经心理学测试，包括EBPM和TBPM任务。

结果

乳腺癌患者与对照组在简易精神状态检查得分（t = -11.684，p < 0.01）、语言流畅性测试得分（t = -7.939，p < 0.01）和数字广度得分（t = -2.538，p < 0.05）上存在显著差异。与健康对照组相比，乳腺癌患者在EBPM上表现较差（t = -7.096，p < 0.01），但在TBPM上无差异（t = -1.921，p > 0.05）。